Abstract:
The cosmetic industry has been investigating the power of epigenetic mechanisms to improve skin health. A considerable amount of data has been accumulating over the years, bringing this innovation to a slow boil, now new epigenetic-based bio-active ingredients are being launched with greater frequency. Many experts suggest epigenetics may be a viable path to effectively reversing skin aging. There are multiple epigenetic mechanisms by which lofty goals can potentially be achieved. Some are surprised that many existing bio-active ingredients are imbued with molecular activity that is epigenetic in nature.
Here, we will address what “epigenetics” means, the dynamics of its associated mechanisms, and why this novel approach to cosmetics is such a game-changer. Central ideas will be discussed, including DNA methylation, histone proteins oscillating between acetylated and methylated states, and post-transcriptional regulation through small non-coding RNA molecules. Additionally, we will present laboratory techniques for evaluating the epigenetic impact of cosmetic ingredients and how to articulate these findings. Moreover, examples of epigenetic products will be expanded to highlight the unique power of this skincare approach and ways to leverage this technology for both diagnostic and therapeutic applications.
Speaker Bio:
Dr. Paul Lawrence – Executive Director of Research and Discovery at Biocogent, LLC
Dr. Lawrence received his doctorate in molecular microbiology from Stony Brook University and before that obtained his Bachelor of Science degree in molecular biology from the University of New Mexico. During his career, he has conducted biological research in academia, industry, and for the United States government. He has executed anti-viral therapeutic and vaccine research at Brookhaven National Laboratory and the Plum Island Animal Disease Center. In industry, he has participated in contract biopharmaceutical projects for the former Collaborative Bioalliance and Dow Chemical. Dr. Lawrence was also the Director of DNA Production for the anti-counterfeiting biotechnology company, Applied DNA Sciences. Currently, he is the Executive Director of Research and Discovery for Biocogent. In his spare time, he is also an adjunct professor at two different colleges teaching microbiology to future nurses and doctors. He also volunteers as an associate technical editor for the Journal of Cosmetic Science and is currently the Vice Chair of the Committee on Scientific Affairs for the Society of Cosmetic Chemists. Over the course of his career, Dr. Lawrence has published more than 30 research manuscripts and review articles, more than 25 online science digests, and has authored a textbook chapter on the molecular pathogenesis of one of the world’s most infectious viruses.